p 16 Search Results


740 y p  (MedChemExpress)
96
MedChemExpress 740 y p
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
740 Y P, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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palmitic acid  (Chem Impex International)
95
Chem Impex International palmitic acid
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Palmitic Acid, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
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phenylalanine d5  (Toronto Research Chemicals)
91
Toronto Research Chemicals phenylalanine d5
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Phenylalanine D5, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 91 stars, based on 1 article reviews
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povidone  (European Directorate for the Quality of Medicines and HealthCare)
90
European Directorate for the Quality of Medicines and HealthCare povidone
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Povidone, supplied by European Directorate for the Quality of Medicines and HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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4000 tes  (European Directorate for the Quality of Medicines and HealthCare)
88
European Directorate for the Quality of Medicines and HealthCare 4000 tes
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
4000 Tes, supplied by European Directorate for the Quality of Medicines and HealthCare, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 88 stars, based on 1 article reviews
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dipalmitoyl sn glycero 3 phosphoethanolamine n  (Croda International Plc)
94
Croda International Plc dipalmitoyl sn glycero 3 phosphoethanolamine n
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Dipalmitoyl Sn Glycero 3 Phosphoethanolamine N, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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94/100 stars
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rac 16 0 pi 5 p d5  (Croda International Plc)
94
Croda International Plc rac 16 0 pi 5 p d5
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Rac 16 0 Pi 5 P D5, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
rac 16 0 pi 5 p d5 - by Bioz Stars, 2026-04
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pi 4 p 1 palmitoyl 2 oleoyl sn glycero 3 phospho 1 myo inositol 4 phosphate  (Croda International Plc)
93
Croda International Plc pi 4 p 1 palmitoyl 2 oleoyl sn glycero 3 phospho 1 myo inositol 4 phosphate
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Pi 4 P 1 Palmitoyl 2 Oleoyl Sn Glycero 3 Phospho 1 Myo Inositol 4 Phosphate, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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93/100 stars
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chloramphenicol  (Chem Impex International)
95
Chem Impex International chloramphenicol
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Chloramphenicol, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chloramphenicol/product/Chem Impex International
Average 95 stars, based on 1 article reviews
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di tert butyl dicarbonate boc2o  (Chem Impex International)
95
Chem Impex International di tert butyl dicarbonate boc2o
<t>Paroxetine</t> antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist <t>(740</t> Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.
Di Tert Butyl Dicarbonate Boc2o, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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andrographolide  (ChromaDex)
93
ChromaDex andrographolide
Representative HPLC chromatograms of diterpene lactones (i.e., <t>andrographolide,</t> 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide) (A) , ethanol (80%) extract (B) and water extract (C) of Andrographis paniculata leaves.
Andrographolide, supplied by ChromaDex, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Paroxetine antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist (740 Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.

Journal: Drug Design, Development and Therapy

Article Title: Paroxetine as a Therapeutic Agent in Inflammatory Osteolysis: Mechanistic Insights and Efficacy

doi: 10.2147/DDDT.S561725

Figure Lengend Snippet: Paroxetine antagonize RANKL-mediated activation of PI3K-AKT signaling pathway through targeting PIK3CA. ( A ) Assessment of phosphorylated level of PI3K and AKT associated with RANKL stimulation by Western blot. ( B ) Quantitative analysis of phosphorylated PI3K and AKT to total PI3K and AKT. ( C ) The 3D images of molecular docking between paroxetine and PIK3CA. ( D ) The 2D docking diagrams specifically highlight the hydrogen bonding sites of paroxetine and PIK3CA. ( E ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and PI3K agonist (740 Y-P). ( F ) Quantitation of TRAP-positive cells after administration with paroxetine and PI3K agonist (740 Y-P). ( G ) Representative TRAP staining images of RANKL-induced osteoclasts administrated with paroxetine and AKT agonist (SC79). ( H ) Quantitation of TRAP-positive cells after administration with paroxetine and AKT agonist (SC79). All bar graphs are presented as mean ± SD; n = 5. *P < 0.05; ***P < 0.001; ****P< 0.0001.

Article Snippet: Paroxetine (HY-122272), SC79 (HY-18749), 740 Y-P (HY-P0175), and DMSO (dimethyl sulfoxide) (DMSO, HY-Y0320) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Activation Assay, Western Blot, Staining, Quantitation Assay

Representative HPLC chromatograms of diterpene lactones (i.e., andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide) (A) , ethanol (80%) extract (B) and water extract (C) of Andrographis paniculata leaves.

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Representative HPLC chromatograms of diterpene lactones (i.e., andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide) (A) , ethanol (80%) extract (B) and water extract (C) of Andrographis paniculata leaves.

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques:

Amount of andrographolide (AP), 14-deoxy-11,12-didehydroandrographolide (DAP), and neoandrographolide (NAP) in 80% of ethanol (EtOH80) and water extracts of Andrographis paniculata leaves analyzed by HPLC.

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Amount of andrographolide (AP), 14-deoxy-11,12-didehydroandrographolide (DAP), and neoandrographolide (NAP) in 80% of ethanol (EtOH80) and water extracts of Andrographis paniculata leaves analyzed by HPLC.

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques: Concentration Assay

Effect of ethanol (80%) extract of Andrographis paniculata leaves, andrographolide and allopurinol on serum uric acid levels in hyperuricemic-induced rats. Data are presented as mean ± SEM ( n = 6). Data were analyzed using one-way ANOVA followed by post hoc Tukey. a Significantly different compared to normal group ( p < 0.05). b Not significantly different compared to normal group ( p > 0.05). c Significantly different compared to hyperuricemic group ( p < 0.05). d Not significantly different compared to allopurinol group ( p > 0.05).

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Effect of ethanol (80%) extract of Andrographis paniculata leaves, andrographolide and allopurinol on serum uric acid levels in hyperuricemic-induced rats. Data are presented as mean ± SEM ( n = 6). Data were analyzed using one-way ANOVA followed by post hoc Tukey. a Significantly different compared to normal group ( p < 0.05). b Not significantly different compared to normal group ( p > 0.05). c Significantly different compared to hyperuricemic group ( p < 0.05). d Not significantly different compared to allopurinol group ( p > 0.05).

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques:

Effect of ethanol (80%) extract of Andrographis paniculata leaves, andrographolide and allopurinol on xanthine oxidase activity in rat’s liver.

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Effect of ethanol (80%) extract of Andrographis paniculata leaves, andrographolide and allopurinol on xanthine oxidase activity in rat’s liver.

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques: Activity Assay, Inhibition

Effect of ethanol (80%) extract of A. paniculata leaves, andrographolide and allopurinol on protein expressions of renal URAT1 (A) , GLUT9 (B) and OAT1 (C) in hyperuricemic-induced rats obtained from Western blot analysis (D) . Data are presented as mean ± SEM ( n = 6). Data were analyzed using one-way ANOVA followed by post hoc Tukey. a Significantly different compared to normal group ( p < 0.05). b Significantly different compared to hyperuricemic group ( p < 0.05).

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Effect of ethanol (80%) extract of A. paniculata leaves, andrographolide and allopurinol on protein expressions of renal URAT1 (A) , GLUT9 (B) and OAT1 (C) in hyperuricemic-induced rats obtained from Western blot analysis (D) . Data are presented as mean ± SEM ( n = 6). Data were analyzed using one-way ANOVA followed by post hoc Tukey. a Significantly different compared to normal group ( p < 0.05). b Significantly different compared to hyperuricemic group ( p < 0.05).

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques: Western Blot

Viability of human fibroblast-like synoviocyte (HFLS) cells after 27 h of exposure to 80% ethanol (EAP) and water (HAP) extracts of Andrographis paniculata leaves, andrographolide (AP), 14-deoxy-11,12-didehydroandrographolide (DAP), neoandrographolide (NAP), dexamethasome (DEXA), and 0.5% DMSO. Data are presented as mean ± SEM ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Viability of human fibroblast-like synoviocyte (HFLS) cells after 27 h of exposure to 80% ethanol (EAP) and water (HAP) extracts of Andrographis paniculata leaves, andrographolide (AP), 14-deoxy-11,12-didehydroandrographolide (DAP), neoandrographolide (NAP), dexamethasome (DEXA), and 0.5% DMSO. Data are presented as mean ± SEM ( n = 3).

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques:

Effect of ethanol (80%) extract of Andrographis paniculata leaves, andrographolide, and indomethacin on swelling rate in MSU-induced inflammation in rat’s knee joint.

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Effect of ethanol (80%) extract of Andrographis paniculata leaves, andrographolide, and indomethacin on swelling rate in MSU-induced inflammation in rat’s knee joint.

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques:

Effect of ethanol (80%) extract of Andrographis paniculata leaves and andrographolide on MSU-induced inflammatory mediator secretion in rat’s knee joint synovial fluid: (A) cytokines and (B) prostaglandin E 2 . Data are presented as mean ± SEM ( n = 6). a Significantly different compared to MSU control group ( p < 0.05). b Not significantly different compared to normal control group ( p > 0.05). c Not significantly different compared to indomethacin group ( p > 0.05).

Journal: Frontiers in Pharmacology

Article Title: Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation

doi: 10.3389/fphar.2021.787125

Figure Lengend Snippet: Effect of ethanol (80%) extract of Andrographis paniculata leaves and andrographolide on MSU-induced inflammatory mediator secretion in rat’s knee joint synovial fluid: (A) cytokines and (B) prostaglandin E 2 . Data are presented as mean ± SEM ( n = 6). a Significantly different compared to MSU control group ( p < 0.05). b Not significantly different compared to normal control group ( p > 0.05). c Not significantly different compared to indomethacin group ( p > 0.05).

Article Snippet: Andrographolide (AP, 99.7%), 14-deoxy-11,12-didehydroandrographolide (DAP, < 99.6%) and neoandrographolide (NAP, ≥ 95%) were HPLC grade and acquired from Chromadex (California, United States).

Techniques: Control